State of Play Review on Haemorrhagic Stroke Basic science of intracerebral haemorrhage
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چکیده
Overview Intracerebral haemorrhage (ICH) causes brain injury in 3 major ways. Firstly there is the mass effect of the initial bleed, haematoma expansion and oedema formation, which increases intracranial pressure causing distortion of brain structures, and mechanical damage to cells. Secondly, there is neuroinflammation that results in secondary brain damage following ICH, through glial activation, cytokine production and disruption of the blood brain barrier (BBB). Finally, rapid dissolution of clotted blood causes the release of breakdown products, such as haemoglobin, haem and iron, which are toxic, cause oxidative stress through the production of free radicals and brain inflammation.
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State of Play Review on Haemorrhagic Stroke Basic science of intracerebral haemorrhage
Overview Intracerebral haemorrhage (ICH) causes brain injury in 3 major ways. Firstly there is the mass effect of the initial bleed, haematoma expansion and oedema formation, which increases intracranial pressure causing distortion of brain structures, and mechanical damage to cells. Secondly, there is neuroinflammation that results in secondary brain damage following ICH, through glial activat...
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